Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands

Monoclonal antibodies (mAbs) to CD137 (a.k.a. 4-1BB) have anti-tumor efficacy in several animal models and have entered clinical trials in patients with advanced cancer. Importantly, anti-CD137 mAbs can also ameliorate autoimmunity in preclinical models. As an approach to better understand the actio...

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Detalles Bibliográficos
Autores principales: Yi, Ling, Zhao, Yanlin, Wang, Xiaojue, Dai, Min, Hellström, Karl Erik, Hellström, Ingegerd, Zhang, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897701/
https://www.ncbi.nlm.nih.gov/pubmed/24466035
http://dx.doi.org/10.1371/journal.pone.0086337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897701/
https://www.ncbi.nlm.nih.gov/pubmed/24466035
http://dx.doi.org/10.1371/journal.pone.0086337

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