Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands

Monoclonal antibodies (mAbs) to CD137 (a.k.a. 4-1BB) have anti-tumor efficacy in several animal models and have entered clinical trials in patients with advanced cancer. Importantly, anti-CD137 mAbs can also ameliorate autoimmunity in preclinical models. As an approach to better understand the actio...

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Autores principales: Yi, Ling, Zhao, Yanlin, Wang, Xiaojue, Dai, Min, Hellström, Karl Erik, Hellström, Ingegerd, Zhang, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897701/
https://www.ncbi.nlm.nih.gov/pubmed/24466035
http://dx.doi.org/10.1371/journal.pone.0086337
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author Yi, Ling
Zhao, Yanlin
Wang, Xiaojue
Dai, Min
Hellström, Karl Erik
Hellström, Ingegerd
Zhang, Hongtao
author_facet Yi, Ling
Zhao, Yanlin
Wang, Xiaojue
Dai, Min
Hellström, Karl Erik
Hellström, Ingegerd
Zhang, Hongtao
author_sort Yi, Ling
collection PubMed
description Monoclonal antibodies (mAbs) to CD137 (a.k.a. 4-1BB) have anti-tumor efficacy in several animal models and have entered clinical trials in patients with advanced cancer. Importantly, anti-CD137 mAbs can also ameliorate autoimmunity in preclinical models. As an approach to better understand the action of agonistic and antagonistic anti-CD137 mAbs we have mapped the binding region of the CD137 ligand (CD137L) to human and mouse CD137. By investigating the binding of CD137L to cysteine rich domain II (CRDII )and CRDIII of CD137, we found that the binding interface was limited and differed between the two species in that mouse CD137L mainly combined with CRDII and human CD137L mainly combined with CRDIII.
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spelling pubmed-38977012014-01-24 Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands Yi, Ling Zhao, Yanlin Wang, Xiaojue Dai, Min Hellström, Karl Erik Hellström, Ingegerd Zhang, Hongtao PLoS One Research Article Monoclonal antibodies (mAbs) to CD137 (a.k.a. 4-1BB) have anti-tumor efficacy in several animal models and have entered clinical trials in patients with advanced cancer. Importantly, anti-CD137 mAbs can also ameliorate autoimmunity in preclinical models. As an approach to better understand the action of agonistic and antagonistic anti-CD137 mAbs we have mapped the binding region of the CD137 ligand (CD137L) to human and mouse CD137. By investigating the binding of CD137L to cysteine rich domain II (CRDII )and CRDIII of CD137, we found that the binding interface was limited and differed between the two species in that mouse CD137L mainly combined with CRDII and human CD137L mainly combined with CRDIII. Public Library of Science 2014-01-21 /pmc/articles/PMC3897701/ /pubmed/24466035 http://dx.doi.org/10.1371/journal.pone.0086337 Text en © 2014 Yi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yi, Ling
Zhao, Yanlin
Wang, Xiaojue
Dai, Min
Hellström, Karl Erik
Hellström, Ingegerd
Zhang, Hongtao
Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands
title Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands
title_full Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands
title_fullStr Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands
title_full_unstemmed Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands
title_short Human and Mouse CD137 Have Predominantly Different Binding CRDs to Their Respective Ligands
title_sort human and mouse cd137 have predominantly different binding crds to their respective ligands
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897701/
https://www.ncbi.nlm.nih.gov/pubmed/24466035
http://dx.doi.org/10.1371/journal.pone.0086337
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