Elevated Levels of Plasma Phenylalanine in Schizophrenia: A Guanosine Triphosphate Cyclohydrolase-1 Metabolic Pathway Abnormality?

BACKGROUND: Phenylalanine and tyrosine are precursor amino acids required for the synthesis of dopamine, the main neurotransmitter implicated in the neurobiology of schizophrenia. Inflammation, increasingly implicated in schizophrenia, can impair the function of the enzyme Phenylalanine hydroxylase...

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Detalles Bibliográficos
Autores principales: Okusaga, Olaoluwa, Muravitskaja, Olesja, Fuchs, Dietmar, Ashraf, Ayesha, Hinman, Sarah, Giegling, Ina, Hartmann, Annette M., Konte, Bettina, Friedl, Marion, Schiffman, Jason, Hong, Elliot, Reeves, Gloria, Groer, Maureen, Dantzer, Robert, Rujescu, Dan, Postolache, Teodor T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897774/
https://www.ncbi.nlm.nih.gov/pubmed/24465804
http://dx.doi.org/10.1371/journal.pone.0085945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897774/
https://www.ncbi.nlm.nih.gov/pubmed/24465804
http://dx.doi.org/10.1371/journal.pone.0085945

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