Cargando…

Elevated Levels of Plasma Phenylalanine in Schizophrenia: A Guanosine Triphosphate Cyclohydrolase-1 Metabolic Pathway Abnormality?

BACKGROUND: Phenylalanine and tyrosine are precursor amino acids required for the synthesis of dopamine, the main neurotransmitter implicated in the neurobiology of schizophrenia. Inflammation, increasingly implicated in schizophrenia, can impair the function of the enzyme Phenylalanine hydroxylase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Okusaga, Olaoluwa, Muravitskaja, Olesja, Fuchs, Dietmar, Ashraf, Ayesha, Hinman, Sarah, Giegling, Ina, Hartmann, Annette M., Konte, Bettina, Friedl, Marion, Schiffman, Jason, Hong, Elliot, Reeves, Gloria, Groer, Maureen, Dantzer, Robert, Rujescu, Dan, Postolache, Teodor T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897774/ https://www.ncbi.nlm.nih.gov/pubmed/24465804 http://dx.doi.org/10.1371/journal.pone.0085945

Ejemplares similares

Phadiatop Seropositivity in Schizophrenia Patients and Controls: A Preliminary Study
por: Okusaga, Olaoluwa, et al.
Publicado: (2014)

A Positive Association between T. gondii Seropositivity and Obesity
por: Reeves, Gloria M., et al.
Publicado: (2013)

Blood Levels of Monoamine Precursors and Smoking in Patients with Schizophrenia
por: Mathai, Ashwin Jacob, et al.
Publicado: (2016)

Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5′-Triphosphate Cyclohydrolase 1 Instigate Its Ubiquitination in Diabetes
por: Zhao, Yu, et al.
Publicado: (2013)

Guanosine-5′-triphosphate cyclohydrolase 1 regulated long noncoding RNAs are potential targets for microglial activation in neuropathic pain
por: Liang, Yan-Hu, et al.
Publicado: (2020)

A Putative Guanosine Triphosphate Cyclohydrolase I Named CaGCH1 Is Involved in Hyphal Branching and Fruiting Development in Cyclocybe aegerita
por: Tao, Nan, et al.
Publicado: (2022)

Seasonality of Suicidal Behavior
por: Woo, Jong-Min, et al.
Publicado: (2012)

PPAR-α Agonist Fenofibrate Upregulates Tetrahydrobiopterin Level through Increasing the Expression of Guanosine 5′-Triphosphate Cyclohydrolase-I in Human Umbilical Vein Endothelial Cells
por: Liu, Jinbo, et al.
Publicado: (2011)

Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia
por: Bourassa, Katelynn A., et al.
Publicado: (2020)

The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates
por: Santner, Tobias, et al.
Publicado: (2012)

Extracellular Guanosine 5′-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine
por: Pietrangelo, Tiziana, et al.
Publicado: (2018)

Toxoplasma gondii, Suicidal Behavior, and Intermediate Phenotypes for Suicidal Behavior
por: Postolache, Teodor T., et al.
Publicado: (2021)

Signal transduction events induced by extracellular guanosine 5′triphosphate in excitable cells
por: Pietrangelo, T., et al.
Publicado: (2006)

Microtubules grow by the addition of bent guanosine triphosphate tubulin to the tips of curved protofilaments
por: McIntosh, J. Richard, et al.
Publicado: (2018)

Influence of light and calcium on guanosine 5'-triphosphate in isolated frog rod outer segments
Publicado: (1979)

Regulation of Ca2+ current in frog ventricular cardiomyocytes by guanosine 5'-triphosphate analogues and isoproterenol
Publicado: (1993)

Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression
por: Ulukan, Burge, et al.
Publicado: (2020)

Trajectory of brain maturation and sex-specific cognitive abnormalities in early-onset psychosis
por: Okusaga, Olaoluwa O.
Publicado: (2017)

A Small Guanosine Triphosphate Binding Protein PagRabE1b Promotes Xylem Development in Poplar
por: Liu, Ying-Li, et al.
Publicado: (2021)

Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-Luc(GTP&ATP) assay
por: Kopra, Kari, et al.
Publicado: (2023)

Genome-Wide Association Study in Vestibular Neuritis: Involvement of the Host Factor for HSV-1 Replication
por: Rujescu, Dan, et al.
Publicado: (2018)

High-risk Allele for Herpes Labialis Severity at the IFNL3/4 Locus is Associated With Vestibular Neuritis
por: Rujescu, Dan, et al.
Publicado: (2020)

Repetitive Transcranial Magnetic Stimulation: A Potential Treatment for Obesity in Patients with Schizophrenia
por: Monem, Ramey G., et al.
Publicado: (2021)

A Variation in FGF14 Is Associated with Downbeat Nystagmus in a Genome-Wide Association Study
por: Strupp, Michael, et al.
Publicado: (2020)

Live-Cell Imaging in Caenorhabditis elegans Reveals the Distinct Roles of Dynamin Self-Assembly and Guanosine Triphosphate Hydrolysis in the Removal of Apoptotic Cells
por: He, Bin, et al.
Publicado: (2010)

In vitro substrate phosphorylation by Ca(2+)/calmodulin-dependent protein kinase kinase using guanosine-5(′)-triphosphate as a phosphate donor
por: Yurimoto, Saki, et al.
Publicado: (2012)

The Protein Partners of GTP Cyclohydrolase I in Rat Organs
por: Du, Jianhai, et al.
Publicado: (2012)

Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolò E., et al.
Publicado: (2014)

Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts
por: Okusaga, Olaoluwa, et al.
Publicado: (2011)

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
por: Kümpornsin, Krittikorn, et al.
Publicado: (2014)

Reply: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolo E., et al.
Publicado: (2015)

Experimental characterization of two archaeal inosine 5'-monophosphate cyclohydrolases
por: Hunter, Caroline A., et al.
Publicado: (2019)

The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)
por: Zhao, Li Na, et al.
Publicado: (2022)

Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19
por: Tizenberg, Boris N., et al.
Publicado: (2021)

Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy
por: Wu, Hsiang-En, et al.
Publicado: (2016)

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
por: Kraft, Vanessa A. N., et al.
Publicado: (2019)

A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
por: Ebenhoch, Rebecca, et al.
Publicado: (2020)

Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case–control sample of schizophrenia
por: Ingason, A, et al.
Publicado: (2015)

Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells
por: Schneider, Erich H., et al.
Publicado: (2020)

Mechanism of Guanosine Triphosphate Hydrolysis by the Visual Proteins Arl3-RP2: Free Energy Reaction Profiles Computed with Ab Initio Type QM/MM Potentials
por: Khrenova, Maria G., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cumn3sgipeps93phgifc7p088a