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ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7
BACKGROUND: The Sec61 channel mediates protein translocation across the endoplasmic reticulum (ER) membrane during secretory protein biogenesis, and likely also during export of misfolded proteins for ER-associated degradation (ERAD). The mechanisms of channel opening for the different modes of tran...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897919/ https://www.ncbi.nlm.nih.gov/pubmed/24314051 http://dx.doi.org/10.1186/1471-2121-14-56 |