The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment

CKS proteins are evolutionarily conserved cyclin-dependent kinase (CDK) subunits whose functions are incompletely understood. Mammals have two CKS proteins. CKS1 acts as a cofactor to the ubiquitin ligase complex SCF(SKP2) to promote degradation of CDK inhibitors, such as p27. Little is known about...

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Detalles Bibliográficos
Autores principales: Frontini, Mattia, Kukalev, Alexander, Leo, Elisabetta, Ng, Yiu-Ming, Cervantes, Marcella, Cheng, Chi-Wai, Holic, Roman, Dormann, Dirk, Tse, Eric, Pommier, Yves, Yu, Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898080/
https://www.ncbi.nlm.nih.gov/pubmed/22898779
http://dx.doi.org/10.1016/j.devcel.2012.06.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898080/
https://www.ncbi.nlm.nih.gov/pubmed/22898779
http://dx.doi.org/10.1016/j.devcel.2012.06.018

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