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The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment

CKS proteins are evolutionarily conserved cyclin-dependent kinase (CDK) subunits whose functions are incompletely understood. Mammals have two CKS proteins. CKS1 acts as a cofactor to the ubiquitin ligase complex SCF(SKP2) to promote degradation of CDK inhibitors, such as p27. Little is known about...

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Detalles Bibliográficos
Autores principales:	Frontini, Mattia, Kukalev, Alexander, Leo, Elisabetta, Ng, Yiu-Ming, Cervantes, Marcella, Cheng, Chi-Wai, Holic, Roman, Dormann, Dirk, Tse, Eric, Pommier, Yves, Yu, Veronica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898080/ https://www.ncbi.nlm.nih.gov/pubmed/22898779 http://dx.doi.org/10.1016/j.devcel.2012.06.018

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