Drosha Regulates Gene Expression Independently of RNA Cleavage Function

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Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we demonstrate that, in addition to miRNA sequences, Drosha specifically binds promoter-proximal regions of many human genes in a transcription-de...

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Detalles Bibliográficos
Autores principales: Gromak, Natalia, Dienstbier, Martin, Macias, Sara, Plass, Mireya, Eyras, Eduardo, Cáceres, Javier F., Proudfoot, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898267/
https://www.ncbi.nlm.nih.gov/pubmed/24360955
http://dx.doi.org/10.1016/j.celrep.2013.11.032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898267/
https://www.ncbi.nlm.nih.gov/pubmed/24360955
http://dx.doi.org/10.1016/j.celrep.2013.11.032

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