Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia

Uveal melanoma (UM) is unique among cancers in displaying reduced endogenous levels of sister chromatid exchange (SCE). Here we demonstrate that FANCD2 expression is reduced in UM and that ectopic expression of FANCD2 increased SCE. Similarly, FANCD2-deficient fibroblasts (PD20) derived from Fanconi...

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Detalles Bibliográficos
Autores principales: Gravells, P, Hoh, L, Solovieva, S, Patil, A, Dudziec, E, Rennie, I G, Sisley, K, Bryant, H E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898318/
https://www.ncbi.nlm.nih.gov/pubmed/23318456
http://dx.doi.org/10.1038/onc.2012.627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898318/
https://www.ncbi.nlm.nih.gov/pubmed/23318456
http://dx.doi.org/10.1038/onc.2012.627

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