Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth

To identify novel signaling pathways necessary for rhabdomyosarcoma (RMS) survival, we performed a loss-of-function screen using an inducible small hairpin RNA (shRNA) library in an alveolar and an embryonal RMS cell line. This screen identified CRKL expression as necessary for growth of alveolar RM...

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Detalles Bibliográficos
Autores principales: Yeung, C L, Ngo, V N, Grohar, P J, Arnaldez, F I, Asante, A, Wan, X, Khan, J, Hewitt, S M, Khanna, C, Staudt, L M, Helman, L J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898328/
https://www.ncbi.nlm.nih.gov/pubmed/23318429
http://dx.doi.org/10.1038/onc.2012.590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898328/
https://www.ncbi.nlm.nih.gov/pubmed/23318429
http://dx.doi.org/10.1038/onc.2012.590

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