Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains

BACKGROUND: Ras is a membrane-associated small G-protein that funnels growth and differentiation signals into downstream signal transduction pathways by cycling between an inactive, GDP-bound and an active, GTP-bound state. Aberrant Ras activity as a result of oncogenic mutations causes de novo cell...

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Detalles Bibliográficos
Autores principales: Augsten, Martin, Böttcher, Anika, Spanbroek, Rainer, Rubio, Ignacio, Friedrich, Karlheinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898410/
https://www.ncbi.nlm.nih.gov/pubmed/24383791
http://dx.doi.org/10.1186/1478-811X-12-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898410/
https://www.ncbi.nlm.nih.gov/pubmed/24383791
http://dx.doi.org/10.1186/1478-811X-12-1

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