Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran

BACKGROUND: Considering the importance to determine the reasons for the higher occurrence of congenital hypothyroidism (CH) in Iran, in this study we report the prevalence of permanent CH (PCH) in Isfahan province 7 years after initiation of CH screening program in Isfahan. METHODS: In this cross-se...

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Autores principales: Hashemipour, Mahin, Ghasemi, Mahmoud, Hovsepian, Silva, Heiydari, Kamal, Sajadi, Ali, Hadian, Rezvaneh, Mansourian, Marjan, Mirshahzadeh, Naghme, Dalvi, Marzie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898441/
https://www.ncbi.nlm.nih.gov/pubmed/24498491
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author Hashemipour, Mahin
Ghasemi, Mahmoud
Hovsepian, Silva
Heiydari, Kamal
Sajadi, Ali
Hadian, Rezvaneh
Mansourian, Marjan
Mirshahzadeh, Naghme
Dalvi, Marzie
author_facet Hashemipour, Mahin
Ghasemi, Mahmoud
Hovsepian, Silva
Heiydari, Kamal
Sajadi, Ali
Hadian, Rezvaneh
Mansourian, Marjan
Mirshahzadeh, Naghme
Dalvi, Marzie
author_sort Hashemipour, Mahin
collection PubMed
description BACKGROUND: Considering the importance to determine the reasons for the higher occurrence of congenital hypothyroidism (CH) in Iran, in this study we report the prevalence of permanent CH (PCH) in Isfahan province 7 years after initiation of CH screening program in Isfahan. METHODS: In this cross-sectional study, children with a primary diagnosis of CH studied. They clinically examined and their medical files were reviewed by a pediatric endocrinologist. Considering screening and follow-up lab data, radiologic findings and the decision of pediatric endocrinologists the final diagnosis of PCH was determined. RESULTS: A total of 464,648 neonates screened in Isfahan province. The coverage percent of the CH screening and recall rate was 98.9% and 2.1%, respectively. A total of 1990 neonates were diagnosed with primary CH. PCH was diagnosed in 410 neonates. The prevalence of PCH and transient CH (TCH) was 1 in 1133 and 1 in 294 live births. The most common etiology of CH was thyroid dyshormonogenesis. CONCLUSIONS: Though the prevalence of PCH is high, but the higher prevalence of CH in Isfahan is commonly due to cases with TCH. Hence, the necessity of determining new strategies for earlier diagnosis of patients with TCH is recommended.
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spelling pubmed-38984412014-02-04 Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran Hashemipour, Mahin Ghasemi, Mahmoud Hovsepian, Silva Heiydari, Kamal Sajadi, Ali Hadian, Rezvaneh Mansourian, Marjan Mirshahzadeh, Naghme Dalvi, Marzie Int J Prev Med Original Article BACKGROUND: Considering the importance to determine the reasons for the higher occurrence of congenital hypothyroidism (CH) in Iran, in this study we report the prevalence of permanent CH (PCH) in Isfahan province 7 years after initiation of CH screening program in Isfahan. METHODS: In this cross-sectional study, children with a primary diagnosis of CH studied. They clinically examined and their medical files were reviewed by a pediatric endocrinologist. Considering screening and follow-up lab data, radiologic findings and the decision of pediatric endocrinologists the final diagnosis of PCH was determined. RESULTS: A total of 464,648 neonates screened in Isfahan province. The coverage percent of the CH screening and recall rate was 98.9% and 2.1%, respectively. A total of 1990 neonates were diagnosed with primary CH. PCH was diagnosed in 410 neonates. The prevalence of PCH and transient CH (TCH) was 1 in 1133 and 1 in 294 live births. The most common etiology of CH was thyroid dyshormonogenesis. CONCLUSIONS: Though the prevalence of PCH is high, but the higher prevalence of CH in Isfahan is commonly due to cases with TCH. Hence, the necessity of determining new strategies for earlier diagnosis of patients with TCH is recommended. Medknow Publications & Media Pvt Ltd 2013-12 /pmc/articles/PMC3898441/ /pubmed/24498491 Text en Copyright: © International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hashemipour, Mahin
Ghasemi, Mahmoud
Hovsepian, Silva
Heiydari, Kamal
Sajadi, Ali
Hadian, Rezvaneh
Mansourian, Marjan
Mirshahzadeh, Naghme
Dalvi, Marzie
Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran
title Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran
title_full Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran
title_fullStr Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran
title_full_unstemmed Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran
title_short Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran
title_sort prevalence of permanent congenital hypothyroidism in isfahan-iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898441/
https://www.ncbi.nlm.nih.gov/pubmed/24498491
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