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Kv2 dysfunction after peripheral axotomy enhances sensory neuron responsiveness to sustained input()

Peripheral nerve injuries caused by trauma are associated with increased sensory neuron excitability and debilitating chronic pain symptoms. Axotomy-induced alterations in the function of ion channels are thought to largely underlie the pathophysiology of these phenotypes. Here, we characterise the...

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Detalles Bibliográficos
Autores principales: Tsantoulas, Christoforos, Zhu, Lan, Yip, Ping, Grist, John, Michael, Gregory J., McMahon, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898477/
https://www.ncbi.nlm.nih.gov/pubmed/24252178
http://dx.doi.org/10.1016/j.expneurol.2013.11.011