HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias

The Lim Domain Only 2 (LMO2) leukaemia oncogene encodes an LIM domain transcriptional cofactor required for early haematopoiesis. During embryogenesis, LMO2 is also expressed in developing tail and limb buds, an expression pattern we now show to be recapitulated in transgenic mice by an enhancer in...

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Detalles Bibliográficos
Autores principales: Calero-Nieto, F J, Joshi, A, Bonadies, N, Kinston, S, Chan, W-I, Gudgin, E, Pridans, C, Landry, J-R, Kikuchi, J, Huntly, B J, Gottgens, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898495/
https://www.ncbi.nlm.nih.gov/pubmed/23708655
http://dx.doi.org/10.1038/onc.2013.175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898495/
https://www.ncbi.nlm.nih.gov/pubmed/23708655
http://dx.doi.org/10.1038/onc.2013.175

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