Cargando…
HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias
The Lim Domain Only 2 (LMO2) leukaemia oncogene encodes an LIM domain transcriptional cofactor required for early haematopoiesis. During embryogenesis, LMO2 is also expressed in developing tail and limb buds, an expression pattern we now show to be recapitulated in transgenic mice by an enhancer in...
Autores principales: | Calero-Nieto, F J, Joshi, A, Bonadies, N, Kinston, S, Chan, W-I, Gudgin, E, Pridans, C, Landry, J-R, Kikuchi, J, Huntly, B J, Gottgens, B |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898495/ https://www.ncbi.nlm.nih.gov/pubmed/23708655 http://dx.doi.org/10.1038/onc.2013.175 |
Ejemplares similares
-
Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia
por: Oram, S H, et al.
Publicado: (2013) -
The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity
por: Bonadies, Nicolas, et al.
Publicado: (2015) -
Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia
por: Sive, J I, et al.
Publicado: (2016) -
XMeis3 Is Necessary for Mesodermal Hox Gene Expression and Function
por: In der Rieden, Paul M. J., et al.
Publicado: (2011) -
Tbx16 regulates hox gene activation in mesodermal progenitor cells
por: Payumo, Alexander Y., et al.
Publicado: (2016)