BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis

BAK activation represents a key step during apoptosis, but how it converts into a mitochondria-permeabilizing pore remains unclear. By further delineating the structural rearrangements involved, we reveal that BAK activation progresses through a series of independent steps: BH3-domain exposure, N-te...

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Detalles Bibliográficos
Autores principales: Weber, Kathrin, Harper, Nicholas, Schwabe, John, Cohen, Gerald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898696/
https://www.ncbi.nlm.nih.gov/pubmed/24120870
http://dx.doi.org/10.1016/j.celrep.2013.09.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898696/
https://www.ncbi.nlm.nih.gov/pubmed/24120870
http://dx.doi.org/10.1016/j.celrep.2013.09.010

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