5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2()

Based on previous reports of certain 5-deazaflavin derivatives being capable of activating the tumour suppressor p53 in cancer cells through inhibition of the p53-specific ubiquitin E3 ligase HDM2, we have conducted an structure–activity relationship (SAR) analysis through systematic modification of...

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Detalles Bibliográficos
Autores principales: Dickens, Michael P., Roxburgh, Patricia, Hock, Andreas, Mezna, Mokdad, Kellam, Barrie, Vousden, Karen H., Fischer, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898830/
https://www.ncbi.nlm.nih.gov/pubmed/24113239
http://dx.doi.org/10.1016/j.bmc.2013.09.038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898830/
https://www.ncbi.nlm.nih.gov/pubmed/24113239
http://dx.doi.org/10.1016/j.bmc.2013.09.038

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