Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes

Centrosomes associate with spindle poles; thus, the presence of two centrosomes promotes bipolar spindle assembly in normal cells. Cancer cells often contain supernumerary centrosomes, and to avoid multipolar mitosis and cell death, these are clustered into two poles by the microtubule motor protein...

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Detalles Bibliográficos
Autores principales: Watts, Ciorsdaidh A., Richards, Frances M., Bender, Andreas, Bond, Peter J., Korb, Oliver, Kern, Oliver, Riddick, Michelle, Owen, Paul, Myers, Rebecca M., Raff, Jordan, Gergely, Fanni, Jodrell, Duncan I., Ley, Steven V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898838/
https://www.ncbi.nlm.nih.gov/pubmed/24210220
http://dx.doi.org/10.1016/j.chembiol.2013.09.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898838/
https://www.ncbi.nlm.nih.gov/pubmed/24210220
http://dx.doi.org/10.1016/j.chembiol.2013.09.012

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