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A Novel Equation for Cooperativity of the Allosteric State Function()

The MWC (Monod–Wyman–Changeux) allosteric model postulates concerted conformational changes between two states: the intrinsically more stable T state with relatively weak ligand binding and the R state with relatively strong ligand binding. The model distinguishes between [Formula: see text] (the fr...

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Detalles Bibliográficos
Autor principal: Edelstein, Stuart J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898861/
https://www.ncbi.nlm.nih.gov/pubmed/24051418
http://dx.doi.org/10.1016/j.jmb.2013.09.010