Atoxic Derivative of Botulinum Neurotoxin A as a Prototype Molecular Vehicle for Targeted Delivery to the Neuronal Cytoplasm

We have previously described genetic constructs and expression systems that enable facile production of recombinant derivatives of botulinum neurotoxins (BoNTs) that retain the structural and trafficking properties of wt BoNTs. In this report we describe the properties of one such derivative, BoNT/A...

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Detalles Bibliográficos
Autores principales: Vazquez-Cintron, Edwin J., Vakulenko, Maksim, Band, Philip A., Stanker, Larry H., Johnson, Eric A., Ichtchenko, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899041/
https://www.ncbi.nlm.nih.gov/pubmed/24465585
http://dx.doi.org/10.1371/journal.pone.0085517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899041/
https://www.ncbi.nlm.nih.gov/pubmed/24465585
http://dx.doi.org/10.1371/journal.pone.0085517

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