Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin

Many pharmaceuticals used to treat cancer target the cell cycle or mitotic spindle dynamics, such as the anti-tumor drug, paclitaxel, which stabilizes microtubules. Here we show that, in cells arrested in mitosis with the spindle toxins, nocodazole, or paclitaxel, the endogenous protein phosphatase...

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Detalles Bibliográficos
Autores principales: Voss, Martin, Campbell, Kathryn, Saranzewa, Nastja, Campbell, David G, Hastie, C James, Peggie, Mark W, Martin-Granados, Cristina, Prescott, Alan R, Cohen, Patricia TW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899200/
https://www.ncbi.nlm.nih.gov/pubmed/23966160
http://dx.doi.org/10.4161/cc.25919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899200/
https://www.ncbi.nlm.nih.gov/pubmed/23966160
http://dx.doi.org/10.4161/cc.25919

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