Cargando…

Effects of Sulforaphane and 3,3′-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3′-diindolylmethane (DIM) are promising chemopreventive agents for the treatment of prostate cancer. Both have been...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wong, Carmen P., Hsu, Anna, Buchanan, Alex, Palomera-Sanchez, Zoraya, Beaver, Laura M., Houseman, E. Andres, Williams, David E., Dashwood, Roderick H., Ho, Emily
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899342/ https://www.ncbi.nlm.nih.gov/pubmed/24466240 http://dx.doi.org/10.1371/journal.pone.0086787

Ejemplares similares

3,3′-Diindolylmethane Induces G(1) Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells
por: Shorey, Lyndsey E., et al.
Publicado: (2012)

Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
por: Hsu, Anna, et al.
Publicado: (2011)

SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells
por: Watson, G W, et al.
Publicado: (2014)

Targeting Bone Remodeling by Isoflavone and 3,3′-Diindolylmethane in the Context of Prostate Cancer Bone Metastasis
por: Li, Yiwei, et al.
Publicado: (2012)

Role of BioResponse 3,3′-Diindolylmethane in the Treatment of Human Prostate Cancer: Clinical Experience
por: Li, Yiwei, et al.
Publicado: (2016)

Induction of apoptosis in human prostate cancer cell line, PC3, by 3,3′-diindolylmethane through the mitochondrial pathway
por: Nachshon-Kedmi, M, et al.
Publicado: (2004)

Multiple therapeutic and preventive effects of 3,3′-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia
por: Zhang, William Weiben, et al.
Publicado: (2014)

Activation of AMP-Activated Protein Kinase by 3,3′-Diindolylmethane (DIM) Is Associated with Human Prostate Cancer Cell Death In Vitro and In Vivo
por: Chen, Di, et al.
Publicado: (2012)

Regulation of carcinogenesis and mediation through Wnt/β-catenin signaling by 3,3′-diindolylmethane in an enzalutamide-resistant prostate cancer cell line
por: Tsao, Chih-Wei, et al.
Publicado: (2021)

3,3′-Diindolylmethane: A Promising Sensitizer of γ-Irradiation
por: Wang, Wenjing, et al.
Publicado: (2015)

Cellular and Molecular Mechanisms of 3,3′-Diindolylmethane in Gastrointestinal Cancer
por: Kim, Soo Mi
Publicado: (2016)

3,3’-Diindolylmethane induces apoptosis and autophagy in fission yeast
por: Emami, Parvaneh, et al.
Publicado: (2021)

3,3'-Diindolylmethane Enhances Tumor Regression After Radiation Through Protecting Normal Cells to Modulate Antitumor Immunity
por: Li, Lijun, et al.
Publicado: (2020)

Chemopreventive Agent 3,3′-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells
por: Gao, Xiang, et al.
Publicado: (2020)

Interactions between β-Lactoglobulin and 3,3′-Diindolylmethane in Model System
por: Wang, Cuina, et al.
Publicado: (2019)

Amelioration of Hyperglycemia-Induced Nephropathy by 3,3′-Diindolylmethane in Diabetic Mice
por: Choi, Kyeong-Mi, et al.
Publicado: (2019)

Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane
por: Williams, David E.
Publicado: (2021)

3,3′-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition
por: WU, TINGTING, et al.
Publicado: (2014)

Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
por: Rajendran, Praveen, et al.
Publicado: (2011)

Physicochemical and Microstructural Properties of Polymerized Whey Protein Encapsulated 3,3′-Diindolylmethane Nanoparticles
por: Khan, Abbas, et al.
Publicado: (2019)

3,3′-Diindolylmethane protects cardiomyocytes from LPS-induced inflammatory response and apoptosis
por: Luo, Qiang, et al.
Publicado: (2018)

3,3′-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and –independent prostate cancer cells
por: Goldberg, Alexander A., et al.
Publicado: (2015)

3,3'-Diindolylmethane plus Eflornithine suppress DNA Replication and Cell Cycle in Esophageal Squamous Cell Carcinoma in vivo
por: Ma, Fayang, et al.
Publicado: (2022)

A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth
por: Yin, Xiao-Fei, et al.
Publicado: (2012)

3,3′-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancer cells by generation of reactive oxygen species
por: Lanza-Jacoby, Susan, et al.
Publicado: (2018)

Erratum: 3,3′-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and–independent prostate cancer cells
por: Goldberg, Alexander A., et al.
Publicado: (2016)

Molecular Simulation Studies of 3,3′-Diindolylmethane as a Potent MicroRNA-21 Antagonist
por: Junaid, Md., et al.
Publicado: (2017)

3,3′-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer
por: Zhang, Jieping, et al.
Publicado: (2022)

Comparative preclinical pharmacokinetics study of 3,3′-diindolylmethane formulations: is personalized treatment and targeted chemoprevention in the horizon?
por: Paltsev, Mikhail, et al.
Publicado: (2013)

3,3′-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro
por: Xia, Zun-En, et al.
Publicado: (2018)

3,3′-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic Streptococcus mutans Biofilm
por: Baruch, Yifat, et al.
Publicado: (2023)

3,3′Diindolylmethane Suppresses Vascular Smooth Muscle Cell Phenotypic Modulation and Inhibits Neointima Formation after Carotid Injury
por: Guan, Hongjing, et al.
Publicado: (2012)

The Indolic Diet-Derivative, 3,3′-Diindolylmethane, Induced Apoptosis in Human Colon Cancer Cells through Upregulation of NDRG1
por: Lerner, A., et al.
Publicado: (2012)

Anticancer effects of 3,3′-diindolylmethane are associated with G1 arrest and mitochondria-dependent apoptosis in human nasopharyngeal carcinoma cells
por: XU, YU, et al.
Publicado: (2013)

Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol
por: Marques, Maud, et al.
Publicado: (2014)

Anti-cancer drug 3,3′-diindolylmethane activates Wnt4 signaling to enhance gastric cancer cell stemness and tumorigenesis
por: Zhu, Yanhua, et al.
Publicado: (2016)

3,3'-Diindolylmethane induces gastric cancer cells death via STIM1 mediated store-operated calcium entry
por: Ye, Yang, et al.
Publicado: (2021)

3,3′-Diindolylmethane improves antitumor immune responses of PD-1 blockade via inhibiting myeloid-derived suppressor cells
por: Sun, Qi, et al.
Publicado: (2022)

Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice
por: Beaver, Laura M, et al.
Publicado: (2017)

The Plant Derived 3-3′-Diindolylmethane (DIM) Behaves as CB(2) Receptor Agonist in Prostate Cancer Cellular Models
por: Tucci, Paolo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4gkg90uiiejsm3e4h3u97kv9dd