Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering

Ammonia is a ubiquitous waste product of protein metabolism that can accumulate in numerous metabolic disorders, causing neurological dysfunction ranging from cognitive impairment to tremor, ataxia, seizures, coma and death(1). The brain is especially vulnerable to ammonia as it readily crosses the...

Descripción completa

Detalles Bibliográficos
Autores principales: Thrane, Vinita Rangroo, Thrane, Alexander S, Wang, Fushun, Cotrina, Maria L, Smith, Nathan A, Chen, Michael, Xu, Qiwu, Kang, Ning, Fujita, Takumi, Nagelhus, Erlend A, Nedergaard, Maiken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899396/
https://www.ncbi.nlm.nih.gov/pubmed/24240184
http://dx.doi.org/10.1038/nm.3400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899396/
https://www.ncbi.nlm.nih.gov/pubmed/24240184
http://dx.doi.org/10.1038/nm.3400

Ejemplares similares