Choline kinase-alpha by regulating cell aggressiveness and drug sensitivity is a potential druggable target for ovarian cancer

BACKGROUND: Aberrant choline metabolism has been proposed as a novel cancer hallmark. We recently showed that epithelial ovarian cancer (EOC) possesses an altered MRS-choline profile, characterised by increased phosphocholine (PCho) content to which mainly contribute over-expression and activation o...

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Detalles Bibliográficos
Autores principales: Granata, A, Nicoletti, R, Tinaglia, V, De Cecco, L, Pisanu, M E, Ricci, A, Podo, F, Canevari, S, Iorio, E, Bagnoli, M, Mezzanzanica, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899765/
https://www.ncbi.nlm.nih.gov/pubmed/24281000
http://dx.doi.org/10.1038/bjc.2013.729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899765/
https://www.ncbi.nlm.nih.gov/pubmed/24281000
http://dx.doi.org/10.1038/bjc.2013.729

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