An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma

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BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive tumour originating in the thoracic mesothelium. Prognosis remains poor with 9- to 12-month median survival, and new targets for treatments are desperately needed. METHODS: Utilising an RNA interference (RNAi)-based screen of 40 genes...

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Detalles Bibliográficos
Autores principales: Linton, A, Cheng, Y Y, Griggs, K, Kirschner, M B, Gattani, S, Srikaran, S, Chuan-Hao Kao, S, McCaughan, B C, Klebe, S, van Zandwijk, N, Reid, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899767/
https://www.ncbi.nlm.nih.gov/pubmed/24327015
http://dx.doi.org/10.1038/bjc.2013.731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899767/
https://www.ncbi.nlm.nih.gov/pubmed/24327015
http://dx.doi.org/10.1038/bjc.2013.731

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