Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

Microglia are crucial for the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Here, we show that the E3 ubiquitin ligase Peli1 is abundantly expressed in microglia and serves as a pivotal mediator of microglial activation during the course of...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Yichuan, Jin, Jin, Chang, Mikyoung, Chang, Jae-Hoon, Hu, Hongbo, Zhou, Xiaofei, Brittain, George C., Stansberg, Christine, Torkildsen, Øivind, Wang, Xiaodong, Brink, Robert, Cheng, Xuhong, Sun, Shao-Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899792/
https://www.ncbi.nlm.nih.gov/pubmed/23603814
http://dx.doi.org/10.1038/nm.3111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899792/
https://www.ncbi.nlm.nih.gov/pubmed/23603814
http://dx.doi.org/10.1038/nm.3111

Ejemplares similares