Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells

BACKGROUND: Aberrant MeCP2 expression in brain is associated with neurodevelopmental disorders including autism. In the brain of stressed mouse and autistic human patients, reduced MeCP2 expression is correlated with Mecp2/MECP2 promoter hypermethylation. Altered expression of MeCP2 isoforms (MeCP2E...

Descripción completa

Detalles Bibliográficos
Autores principales: Liyanage, Vichithra R B, Zachariah, Robby M, Rastegar, Mojgan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900258/
https://www.ncbi.nlm.nih.gov/pubmed/24238559
http://dx.doi.org/10.1186/2040-2392-4-46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900258/
https://www.ncbi.nlm.nih.gov/pubmed/24238559
http://dx.doi.org/10.1186/2040-2392-4-46

Ejemplares similares