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Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells

BACKGROUND: Aberrant MeCP2 expression in brain is associated with neurodevelopmental disorders including autism. In the brain of stressed mouse and autistic human patients, reduced MeCP2 expression is correlated with Mecp2/MECP2 promoter hypermethylation. Altered expression of MeCP2 isoforms (MeCP2E...

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Detalles Bibliográficos
Autores principales:	Liyanage, Vichithra R B, Zachariah, Robby M, Rastegar, Mojgan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900258/ https://www.ncbi.nlm.nih.gov/pubmed/24238559 http://dx.doi.org/10.1186/2040-2392-4-46

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