Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa

BACKGROUND: The peroxisome proliferator-activated receptor gamma (PPARG), Pro12Ala and the insulin receptor substrate (IRS1), Gly972Arg confer opposite effects on insulin resistance and type 2 diabetes mellitus (T2DM). We investigated the independent and joint effects of PPARG Pro12Ala and IRS1 Gly9...

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Detalles Bibliográficos
Autores principales: Vergotine, Zelda, Yako, Yandiswa Y, Kengne, Andre P, Erasmus, Rajiv T, Matsha, Tandi E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900266/
https://www.ncbi.nlm.nih.gov/pubmed/24447396
http://dx.doi.org/10.1186/1471-2156-15-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900266/
https://www.ncbi.nlm.nih.gov/pubmed/24447396
http://dx.doi.org/10.1186/1471-2156-15-10

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