Cargando…

Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa

BACKGROUND: The peroxisome proliferator-activated receptor gamma (PPARG), Pro12Ala and the insulin receptor substrate (IRS1), Gly972Arg confer opposite effects on insulin resistance and type 2 diabetes mellitus (T2DM). We investigated the independent and joint effects of PPARG Pro12Ala and IRS1 Gly9...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vergotine, Zelda, Yako, Yandiswa Y, Kengne, Andre P, Erasmus, Rajiv T, Matsha, Tandi E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900266/ https://www.ncbi.nlm.nih.gov/pubmed/24447396 http://dx.doi.org/10.1186/1471-2156-15-10

Ejemplares similares

Rare Mutations of Peroxisome Proliferator-Activated Receptor Gamma: Frequencies and Relationship with Insulin Resistance and Diabetes Risk in the Mixed Ancestry Population from South Africa
por: Vergotine, Z., et al.
Publicado: (2014)

APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans
por: Matsha, Tandi E, et al.
Publicado: (2015)

Chronic kidney diseases in mixed ancestry south African populations: prevalence, determinants and concordance between kidney function estimators
por: Matsha, Tandi E, et al.
Publicado: (2013)

Polymorphisms in the Non-Muscle Myosin Heavy Chain Gene (MYH9) Are Associated with Lower Glomerular Filtration Rate in Mixed Ancestry Diabetic Subjects from South Africa
por: Matsha, Tandi Edith, et al.
Publicado: (2012)

Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism
por: Lin, Ta-Chin, et al.
Publicado: (2006)

Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population
por: Lin, Ming-Wei, et al.
Publicado: (2014)

Optimal Waist-to-Height Ratio Values for Cardiometabolic Risk Screening in an Ethnically Diverse Sample of South African Urban and Rural School Boys and Girls
por: Matsha, Tandi E., et al.
Publicado: (2013)

MicroRNA profiling and their pathways in South African individuals with prediabetes and newly diagnosed type 2 diabetes mellitus
por: Matsha, Tandi E., et al.
Publicado: (2018)

Insulin Receptor Substrate 1 Gly972Arg (rs1801278) Polymorphism Is Associated with Obesity and Insulin Resistance in Kashmiri Women with Polycystic Ovary Syndrome
por: Rasool, Shayaq Ul Abeer, et al.
Publicado: (2022)

High Molecular Weight Adiponectin Levels are Neither Influenced by Adiponectin Polymorphisms Nor Associated with Insulin Resistance in Mixed-ancestry Hyperglycemic Subjects from South Africa
por: Zemlin, Annalise E, et al.
Publicado: (2016)

IRS1 gene polymorphisms Gly972Arg and Ala513Pro are not associated with insulin resistance and type 2 diabetes risk in non-obese Turkish population
por: Arikoglu, Hilal, et al.
Publicado: (2014)

The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects
por: Syahrul, et al.
Publicado: (2018)

The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling
por: Thameem, Farook, et al.
Publicado: (2012)

Independent external validation and comparison of prevalent diabetes risk prediction models in a mixed-ancestry population of South Africa
por: Masconi, Katya, et al.
Publicado: (2015)

Haematological profile of chronic kidney disease in a mixed-ancestry South African population: a cross-sectional study
por: George, Cindy, et al.
Publicado: (2018)

Effect of model updating strategies on the performance of prevalent diabetes risk prediction models in a mixed-ancestry population of South Africa
por: Masconi, Katya L., et al.
Publicado: (2019)

Effects of Different Missing Data Imputation Techniques on the Performance of Undiagnosed Diabetes Risk Prediction Models in a Mixed-Ancestry Population of South Africa
por: Masconi, Katya L., et al.
Publicado: (2015)

Lack of association between the insulin receptor substrates-1 Gly972Arg polymorphism and type-2 diabetes mellitus among Saudis from Eastern Saudi Arabia
por: Alsalman, Hawra A., et al.
Publicado: (2015)

Glucose Tolerance, MTHFR C677T and NOS3 G894T Polymorphisms, and Global DNA Methylation in Mixed Ancestry African Individuals
por: Matsha, Tandi E., et al.
Publicado: (2016)

Validation of two prediction models of undiagnosed chronic kidney disease in mixed-ancestry South Africans
por: Mogueo, Amelie, et al.
Publicado: (2015)

Genome-Wide DNA Methylation in Mixed Ancestry Individuals with Diabetes and Prediabetes from South Africa
por: Matsha, Tandi E., et al.
Publicado: (2016)

Changes in Obesity Phenotype Distribution in Mixed-ancestry South Africans in Cape Town Between 2008/09 and 2014/16
por: Davids, Saarah Fatoma, et al.
Publicado: (2019)

The 7-Year Change in the Prevalence of Insulin Resistance, Inflammatory Biomarkers, and Their Determinants in an Urban South African Population
por: Davids, Saarah Fatoma Gadija, et al.
Publicado: (2020)

Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans
por: Weale, Cecil J., et al.
Publicado: (2019)

Influence of peroxisome proliferator-activated receptor-γ exon 2 and exon 6 and insulin receptor substrate (IRS)-1 Gly972Arg polymorphisms on insulin resistance and beta-cell function in southern mediterranean women with polycystic ovary syndrome
por: Giandalia, Annalisa, et al.
Publicado: (2018)

Combining HbA(1c) and glycated albumin improves detection of dysglycaemia in mixed-ancestry South Africans
por: Kengne, Andre Pascal, et al.
Publicado: (2022)

Platelet, monocyte and neutrophil activation and glucose tolerance in South African Mixed Ancestry individuals
por: Davison, Glenda M., et al.
Publicado: (2017)

An African perspective on the genetic risk of chronic kidney disease: a systematic review
por: George, Cindy, et al.
Publicado: (2018)

Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians
por: Bhatt, Surya Prakash, et al.
Publicado: (2021)

Arg(972) Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence
por: Liu, Wei, et al.
Publicado: (2013)

Insulin Receptor Substrate-1 (IRS-1) Gly927Arg: Correlation with Gestational Diabetes Mellitus in Saudi Women
por: Alharbi, Khalid Khalaf, et al.
Publicado: (2014)

Paraoxonase1 Genetic Polymorphisms in a Mixed Ancestry African Population
por: Macharia, M., et al.
Publicado: (2014)

Differential prevalence and associations of overweight and obesity by gender and population group among school learners in South Africa: a cross-sectional study
por: Negash, Sarah, et al.
Publicado: (2017)

The discriminatory power of visceral adipose tissue area vs anthropometric measures as a diagnostic marker for metabolic syndrome in South African women
por: Davidson, Florence E., et al.
Publicado: (2019)

Reporting and handling of missing data in predictive research for prevalent undiagnosed type 2 diabetes mellitus: a systematic review
por: Masconi, Katya L, et al.
Publicado: (2015)

The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease: a cross-sectional study
por: George, Cindy, et al.
Publicado: (2020)

MicroRNAs associated with chronic kidney disease in the general population and high-risk subgroups: protocol for a systematic review and meta-analysis
por: Motshwari, Dipuo Dephney, et al.
Publicado: (2022)

Prevalence of Oral Mucosal Lesions and Relation to Serum Cotinine Levels—Findings from a Cross-Sectional Study in South Africa
por: Pontes, Carla Cruvinel, et al.
Publicado: (2020)

Chronic Kidney Disease Modifies The Relationship Between Body Fat Distribution and Blood Pressure: A Cross-Sectional Analysis
por: George, Cindy, et al.
Publicado: (2020)

MicroRNAs Associated with Chronic Kidney Disease in the General Population and High-Risk Subgroups—A Systematic Review
por: Motshwari, Dipuo D., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_b3q6l90nbmskni06u92vc21rhd