A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast

Unbiased lipidomic approaches have identified impairments in glycerophosphocholine second messenger metabolism in patients with Alzheimer's disease. Specifically, we have shown that amyloid-β42 signals the intraneuronal accumulation of PC(O-16:0/2:0) which is associated with neurotoxicity. Simi...

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Detalles Bibliográficos
Autores principales: Kennedy, Michael A., Gable, Kenneth, Niewola-Staszkowska, Karolina, Abreu, Susana, Johnston, Anne, Harris, Linda J., Reggiori, Fulvio, Loewith, Robbie, Dunn, Teresa, Bennett, Steffany A. L., Baetz, Kristin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900389/
https://www.ncbi.nlm.nih.gov/pubmed/24465216
http://dx.doi.org/10.1371/journal.pgen.1004010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900389/
https://www.ncbi.nlm.nih.gov/pubmed/24465216
http://dx.doi.org/10.1371/journal.pgen.1004010

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