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Down-Regulation of Rad51 Activity during Meiosis in Yeast Prevents Competition with Dmc1 for Repair of Double-Strand Breaks
Interhomolog recombination plays a critical role in promoting proper meiotic chromosome segregation but a mechanistic understanding of this process is far from complete. In vegetative cells, Rad51 is a highly conserved recombinase that exhibits a preference for repairing double strand breaks (DSBs)...
Autores principales: | Liu, Yan, Gaines, William A., Callender, Tracy, Busygina, Valeria, Oke, Ashwini, Sung, Patrick, Fung, Jennifer C., Hollingsworth, Nancy M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900393/ https://www.ncbi.nlm.nih.gov/pubmed/24465215 http://dx.doi.org/10.1371/journal.pgen.1004005 |
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