Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases

BACKGROUND: ‘Phylogenetic trees’ are commonly used for the analysis of chemogenomics datasets and to relate protein targets to each other, based on the (shared) bioactivities of their ligands. However, no real assessment as to the suitability of this representation has been performed yet in this are...

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Detalles Bibliográficos
Autores principales: Paricharak, Shardul, Klenka, Tom, Augustin, Martin, Patel, Umesh A, Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900467/
https://www.ncbi.nlm.nih.gov/pubmed/24330772
http://dx.doi.org/10.1186/1758-2946-5-49

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900467/
https://www.ncbi.nlm.nih.gov/pubmed/24330772
http://dx.doi.org/10.1186/1758-2946-5-49

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