Molecular Dynamics Simulation of the Allosteric Regulation of eIF4A Protein from the Open to Closed State, Induced by ATP and RNA Substrates

BACKGROUND: Eukaryotic initiation factor 4A (eIF4A) plays a key role in the process of protein translation initiation by facilitating the melting of the 5′ proximal secondary structure of eukaryotic mRNA for ribosomal subunit attachment. It was experimentally postulated that the closed conformation...

Descripción completa

Detalles Bibliográficos
Autores principales: Meng, Hongqing, Li, Chaoqun, Wang, Yan, Chen, Guangju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900488/
https://www.ncbi.nlm.nih.gov/pubmed/24465900
http://dx.doi.org/10.1371/journal.pone.0086104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900488/
https://www.ncbi.nlm.nih.gov/pubmed/24465900
http://dx.doi.org/10.1371/journal.pone.0086104

Ejemplares similares