Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques

HIV sequence diversity and potential decoy epitopes are hurdles in the development of an effective AIDS vaccine. A DNA vaccine candidate comprising of highly conserved p24(gag) elements (CE) induced robust immunity in all 10 vaccinated macaques, whereas full-length gag DNA vaccination elicited respo...

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Detalles Bibliográficos
Autores principales: Kulkarni, Viraj, Valentin, Antonio, Rosati, Margherita, Alicea, Candido, Singh, Ashish K., Jalah, Rashmi, Broderick, Kate E., Sardesai, Niranjan Y., Le Gall, Sylvie, Mothe, Beatriz, Brander, Christian, Rolland, Morgane, Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900501/
https://www.ncbi.nlm.nih.gov/pubmed/24465991
http://dx.doi.org/10.1371/journal.pone.0086254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900501/
https://www.ncbi.nlm.nih.gov/pubmed/24465991
http://dx.doi.org/10.1371/journal.pone.0086254

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