SH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion

IGF-1 and insulin promote β-cell expansion by inhibiting β-cell death and stimulating β-cell proliferation, and the phosphatidylinositol (PI) 3-kinase/Akt pathway mediates insulin and IGF-1 action. Impaired β-cell expansion is a risk factor for type 2 diabetes. Here, we identified SH2B1, which is hi...

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Detalles Bibliográficos
Autores principales: Chen, Zheng, Morris, David L., Jiang, Lin, Liu, Yong, Rui, Liangyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900537/
https://www.ncbi.nlm.nih.gov/pubmed/24150605
http://dx.doi.org/10.2337/db13-0666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900537/
https://www.ncbi.nlm.nih.gov/pubmed/24150605
http://dx.doi.org/10.2337/db13-0666

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