Cargando…

SH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion

IGF-1 and insulin promote β-cell expansion by inhibiting β-cell death and stimulating β-cell proliferation, and the phosphatidylinositol (PI) 3-kinase/Akt pathway mediates insulin and IGF-1 action. Impaired β-cell expansion is a risk factor for type 2 diabetes. Here, we identified SH2B1, which is hi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zheng, Morris, David L., Jiang, Lin, Liu, Yong, Rui, Liangyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900537/ https://www.ncbi.nlm.nih.gov/pubmed/24150605 http://dx.doi.org/10.2337/db13-0666

Ejemplares similares

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass
por: Oh, Eunjin, et al.
Publicado: (2018)

Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets
por: Tian, Geng, et al.
Publicado: (2011)

Islet-1 Is Essential for Pancreatic β-Cell Function
por: Ediger, Benjamin N., et al.
Publicado: (2014)

Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure
por: Hodik, M, et al.
Publicado: (2016)

Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for β-Cell Function
por: Olerud, Johan, et al.
Publicado: (2011)

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo
por: Matsuoka, Taka-aki, et al.
Publicado: (2017)

Activation of Protein Kinase C-ζ in Pancreatic β-Cells In Vivo Improves Glucose Tolerance and Induces β-Cell Expansion via mTOR Activation
por: Velazquez-Garcia, Silvia, et al.
Publicado: (2011)

Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo
por: Zhu, Shuaishuai, et al.
Publicado: (2016)

Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor
por: Hunter, Chad S., et al.
Publicado: (2013)

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes
por: Dahan, Tehila, et al.
Publicado: (2017)

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells
por: Dolai, Subhankar, et al.
Publicado: (2016)

Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin
por: Jiang, Yuying, et al.
Publicado: (2008)

β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass
por: Peyot, Marie-Line, et al.
Publicado: (2010)

The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote β-Cell Survival
por: McKimpson, Wendy M., et al.
Publicado: (2013)

Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet β-Cells
por: Dezaki, Katsuya, et al.
Publicado: (2011)

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth
por: Hang, Yan, et al.
Publicado: (2014)

Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells
por: Banerjee, Ronadip R., et al.
Publicado: (2016)

Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation
por: Zhang, Pili, et al.
Publicado: (2015)

Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation
por: Bottino, Rita, et al.
Publicado: (2009)

Neutralizing Th2 Inflammation in Neonatal Islets Prevents β-Cell Failure in Adult IUGR Rats
por: Jaeckle Santos, Lane J., et al.
Publicado: (2014)

Formation of Composite Endothelial Cell–Mesenchymal Stem Cell Islets: A Novel Approach to Promote Islet Revascularization
por: Johansson, Ulrika, et al.
Publicado: (2008)

In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice
por: He, Kai Hui Hu, et al.
Publicado: (2011)

Vascular Endothelial Growth Factor–Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of β-Cell Mass
por: Agudo, Judith, et al.
Publicado: (2012)

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca(2+)-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells
por: Demozay, Damien, et al.
Publicado: (2011)

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells
por: Paul, Leena, et al.
Publicado: (2016)

Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in K(ATP)-Induced Neonatal Diabetes
por: Yan, Zihan, et al.
Publicado: (2022)

β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes
por: Gitelman, Stephen E., et al.
Publicado: (2023)

Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
por: Tersey, Sarah A., et al.
Publicado: (2012)

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function
por: Scoville, David W., et al.
Publicado: (2015)

Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning
por: Spaeth, Jason M., et al.
Publicado: (2017)

Single Molecule–Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet β-Cells
por: Li, Fangjia, et al.
Publicado: (2021)

ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation
por: Metukuri, Mallikarjuna R., et al.
Publicado: (2012)

Pak3 Promotes Cell Cycle Exit and Differentiation of β-Cells in the Embryonic Pancreas and Is Necessary to Maintain Glucose Homeostasis in Adult Mice
por: Piccand, Julie, et al.
Publicado: (2014)

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function
por: Spaeth, Jason M., et al.
Publicado: (2019)

Soluble Factors Secreted by T Cells Promote β-Cell Proliferation
por: Dirice, Ercument, et al.
Publicado: (2014)

Increased β-Cell Mass by Islet Transplantation and PLAG1 Overexpression Causes Hyperinsulinemic Normoglycemia and Hepatic Insulin Resistance in Mice
por: Declercq, Jeroen, et al.
Publicado: (2010)

Cyclin-Dependent Kinase 5 Promotes Pancreatic β-Cell Survival via Fak-Akt Signaling Pathways
por: Daval, Marie, et al.
Publicado: (2011)

Connective Tissue Growth Factor Modulates Adult β-Cell Maturity and Proliferation to Promote β-Cell Regeneration in Mice
por: Riley, Kimberly G., et al.
Publicado: (2015)

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired β-Cell Function
por: Kruit, Janine K., et al.
Publicado: (2012)

Inhibition of Ca(2+)-Independent Phospholipase A(2)β (iPLA(2)β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice
por: Bone, Robert N., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ekj3r21h7nmrkjan48r4533fd0