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SH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion

IGF-1 and insulin promote β-cell expansion by inhibiting β-cell death and stimulating β-cell proliferation, and the phosphatidylinositol (PI) 3-kinase/Akt pathway mediates insulin and IGF-1 action. Impaired β-cell expansion is a risk factor for type 2 diabetes. Here, we identified SH2B1, which is hi...

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Detalles Bibliográficos
Autores principales:	Chen, Zheng, Morris, David L., Jiang, Lin, Liu, Yong, Rui, Liangyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900537/ https://www.ncbi.nlm.nih.gov/pubmed/24150605 http://dx.doi.org/10.2337/db13-0666

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