Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

Sustained increases in glucose flux via the aldose reductase (AR) pathway have been linked to diabetic vascular complications. Previous studies revealed that glucose flux via AR mediates endothelial dysfunction and leads to lesional hemorrhage in diabetic human AR (hAR) expressing mice in an apoE(−/...

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Detalles Bibliográficos
Autores principales: Vedantham, Srinivasan, Thiagarajan, Devi, Ananthakrishnan, Radha, Wang, Lingjie, Rosario, Rosa, Zou, Yu Shan, Goldberg, Ira, Yan, Shi Fang, Schmidt, Ann Marie, Ramasamy, Ravichandran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900544/
https://www.ncbi.nlm.nih.gov/pubmed/24186862
http://dx.doi.org/10.2337/db13-0032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900544/
https://www.ncbi.nlm.nih.gov/pubmed/24186862
http://dx.doi.org/10.2337/db13-0032

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