Cargando…

Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

Sustained increases in glucose flux via the aldose reductase (AR) pathway have been linked to diabetic vascular complications. Previous studies revealed that glucose flux via AR mediates endothelial dysfunction and leads to lesional hemorrhage in diabetic human AR (hAR) expressing mice in an apoE(−/...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vedantham, Srinivasan, Thiagarajan, Devi, Ananthakrishnan, Radha, Wang, Lingjie, Rosario, Rosa, Zou, Yu Shan, Goldberg, Ira, Yan, Shi Fang, Schmidt, Ann Marie, Ramasamy, Ravichandran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900544/ https://www.ncbi.nlm.nih.gov/pubmed/24186862 http://dx.doi.org/10.2337/db13-0032

Ejemplares similares

Aldose reductase modulates acute activation of mesenchymal markers via the β-catenin pathway during cardiac ischemia-reperfusion
por: Thiagarajan, Devi, et al.
Publicado: (2017)

Cardiomyocyte Aldose Reductase Causes Heart Failure and Impairs Recovery from Ischemia
por: Son, Ni-Huiping, et al.
Publicado: (2012)

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium
por: Bucciarelli, Loredana G., et al.
Publicado: (2008)

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse
por: Reiniger, Nina, et al.
Publicado: (2010)

Aldose Reductase: An Emerging Target for Development of Interventions for Diabetic Cardiovascular Complications
por: Jannapureddy, Sravya, et al.
Publicado: (2021)

Stratified analyses for selecting appropriate target patients with diabetic peripheral neuropathy for long-term treatment with an aldose reductase inhibitor, epalrestat
por: Hotta, N, et al.
Publicado: (2008)

Hyperhomocysteinemia Potentiates Hyperglycemia-Induced Inflammatory Monocyte Differentiation and Atherosclerosis
por: Fang, Pu, et al.
Publicado: (2014)

Proinflammatory and Prothrombotic Effects of Hypoglycemia
por: Dandona, Paresh, et al.
Publicado: (2010)

Combination Therapies Prevent the Neuropathic, Proinflammatory Characteristics of Bone Marrow in Streptozotocin-Induced Diabetic Rats
por: Dominguez, James M., et al.
Publicado: (2015)

Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators
por: Busik, Julia V., et al.
Publicado: (2008)

Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism
por: Glaser, Nicole, et al.
Publicado: (2012)

Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity
por: Thiagarajan, R., et al.
Publicado: (2019)

Parp Inhibition Prevents Ten-Eleven Translocase Enzyme Activation and Hyperglycemia-Induced DNA Demethylation
por: Dhliwayo, Nyembezi, et al.
Publicado: (2014)

Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia
por: Mauras, Nelly, et al.
Publicado: (2015)

Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Müller Cell–Derived Inflammatory Cytokine Production in Diabetes
por: Zhong, Yimin, et al.
Publicado: (2012)

Neuronatin: A New Inflammation Gene Expressed on the Aortic Endothelium of Diabetic Mice
por: Mzhavia, Nino, et al.
Publicado: (2008)

C-Peptide Prevents Hyperglycemia-Induced Endothelial Apoptosis Through Inhibition of Reactive Oxygen Species–Mediated Transglutaminase 2 Activation
por: Bhatt, Mahendra Prasad, et al.
Publicado: (2013)

GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop
por: Giacco, Ferdinando, et al.
Publicado: (2015)

Klotho prevents epithelial–mesenchymal transition through Egr-1 downregulation in diabetic kidney disease
por: Li, Yang, et al.
Publicado: (2021)

Activation of NF-E2–Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease
por: Xue, Mingzhan, et al.
Publicado: (2008)

Diabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice
por: Parathath, Saj, et al.
Publicado: (2011)

Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
por: Reddy, G. Bhanuprakash, et al.
Publicado: (2008)

Evidence That Hyperglycemia After Recovery From Hypoglycemia Worsens Endothelial Function and Increases Oxidative Stress and Inflammation in Healthy Control Subjects and Subjects With Type 1 Diabetes
por: Ceriello, Antonio, et al.
Publicado: (2012)

Physiological and Pathological Roles of Aldose Reductase
por: Singh, Mahavir, et al.
Publicado: (2021)

In Search of Differential Inhibitors of Aldose Reductase
por: Balestri, Francesco, et al.
Publicado: (2022)

Genome-Wide Transcriptional Analysis of Differentially Expressed Genes in Diabetic, Healing Corneal Epithelial Cells: Hyperglycemia-Suppressed TGFβ3 Expression Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas
por: Bettahi, Ilham, et al.
Publicado: (2014)

Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation
por: Gopal, Keshav, et al.
Publicado: (2023)

Structure of aldose reductase from Giardia lamblia
por: Ferrell, M., et al.
Publicado: (2011)

Aldose Reductase, Oxidative Stress, and Diabetic Mellitus
por: Tang, Wai Ho, et al.
Publicado: (2012)

Inhibition of Aldose Reductase by Gentiana lutea Extracts
por: Akileshwari, Chandrasekhar, et al.
Publicado: (2012)

Aldose Reductase Differential Inhibitors in Green Tea
por: Balestri, Francesco, et al.
Publicado: (2020)

Human aldose reductase unfolds through an intermediate
por: Sekhon, Gurprit, et al.
Publicado: (2019)

Molecular docking analysis of flavonoids with aldose reductase
por: Kannayiram, Kasthuri, et al.
Publicado: (2022)

Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment
por: Liang, Chien-Ping, et al.
Publicado: (2012)

Litsea japonica Extract Inhibits Aldose Reductase Activity and Hyperglycemia-Induced Lenticular Sorbitol Accumulation in db/db Mice
por: Kim, Junghyun, et al.
Publicado: (2015)

The Formin, DIAPH1, is a Key Modulator of Myocardial Ischemia/Reperfusion Injury
por: O'Shea, Karen M., et al.
Publicado: (2017)

Trends in the relation between hyperglycemia correction and active Charcot neuroarthropathy: results from the EPICHAR study
por: Dardari, Dured, et al.
Publicado: (2022)

Egr-1 and RNA POL II facilitate glioma cell GDNF transcription induced by histone hyperacetylation in promoter II
por: Zhang, Bao-Le, et al.
Publicado: (2017)

Aldose Reductase Gene Polymorphisms and Diabetic Retinopathy Susceptibility
por: Abhary, Sotoodeh, et al.
Publicado: (2010)

Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct
por: Balestri, Francesco, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8sep4ksq7a9d2pkjcs77qhn224