A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis

Impaired angiogenesis in ischemic tissue is a hallmark of diabetes. Thioredoxin-interacting protein (TXNIP) is an exquisitely glucose-sensitive gene that is overexpressed in diabetes. As TXNIP modulates the activity of the key angiogenic cytokine vascular endothelial growth factor (VEGF), we hypothe...

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Detalles Bibliográficos
Autores principales: Dunn, Louise L., Simpson, Philippa J.L., Prosser, Hamish C., Lecce, Laura, Yuen, Gloria S.C., Buckle, Andrew, Sieveking, Daniel P., Vanags, Laura Z., Lim, Patrick R., Chow, Renee W.Y., Lam, Yuen Ting, Clayton, Zoe, Bao, Shisan, Davies, Michael J., Stadler, Nadina, Celermajer, David S., Stocker, Roland, Bursill, Christina A., Cooke, John P., Ng, Martin K.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900553/
https://www.ncbi.nlm.nih.gov/pubmed/24198286
http://dx.doi.org/10.2337/db13-0417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900553/
https://www.ncbi.nlm.nih.gov/pubmed/24198286
http://dx.doi.org/10.2337/db13-0417

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