Clostridium perfringens Phospholipase C Induced ROS Production and Cytotoxicity Require PKC, MEK1 and NFκB Activation

Clostridium perfringens phospholipase C (CpPLC), also called α-toxin, is the most toxic extracellular enzyme produced by this bacteria and is essential for virulence in gas gangrene. At lytic concentrations, CpPLC causes membrane disruption, whereas at sublytic concentrations this toxin causes oxida...

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Detalles Bibliográficos
Autores principales: Monturiol-Gross, Laura, Flores-Díaz, Marietta, Pineda-Padilla, Maria Jose, Castro-Castro, Ana Cristina, Alape-Giron, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900566/
https://www.ncbi.nlm.nih.gov/pubmed/24466113
http://dx.doi.org/10.1371/journal.pone.0086475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900566/
https://www.ncbi.nlm.nih.gov/pubmed/24466113
http://dx.doi.org/10.1371/journal.pone.0086475

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