The Neutron Structure of Urate Oxidase Resolves a Long-Standing Mechanistic Conundrum and Reveals Unexpected Changes in Protonation

Urate oxidase transforms uric acid to 5-hydroxyisourate without the help of cofactors, but the catalytic mechanism has remained enigmatic, as the protonation state of the substrate could not be reliably deduced. We have determined the neutron structure of urate oxidase, providing unique information...

Descripción completa

Detalles Bibliográficos
Autores principales: Oksanen, Esko, Blakeley, Matthew P., El-Hajji, Mohamed, Ryde, Ulf, Budayova-Spano, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900588/
https://www.ncbi.nlm.nih.gov/pubmed/24466188
http://dx.doi.org/10.1371/journal.pone.0086651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900588/
https://www.ncbi.nlm.nih.gov/pubmed/24466188
http://dx.doi.org/10.1371/journal.pone.0086651

Ejemplares similares