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Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts
The influential role of the epigenome in orchestrating genome-wide transcriptional activation instigates the demand for the artificial genetic switches with distinct DNA sequence recognition. Recently, we developed a novel class of epigenetically active small molecules called SAHA-PIPs by conjugatin...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900999/ https://www.ncbi.nlm.nih.gov/pubmed/24457603 http://dx.doi.org/10.1038/srep03843 |