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Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The pr...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Portland Press Ltd.
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901396/ https://www.ncbi.nlm.nih.gov/pubmed/24450636 http://dx.doi.org/10.1042/BST20130228 |