Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development

Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The pr...

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Detalles Bibliográficos
Autor principal: Gileadi, Opher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Biochemical Society Focused Meeting
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901396/
https://www.ncbi.nlm.nih.gov/pubmed/24450636
http://dx.doi.org/10.1042/BST20130228
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author Gileadi, Opher
author_facet Gileadi, Opher
author_sort Gileadi, Opher
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description Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The present review surveys recent data on the structure and regulation of sGC, and the prospects of new avenues for therapeutic intervention.
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spelling pubmed-39013962014-01-28 Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development Gileadi, Opher Biochem Soc Trans Biochemical Society Focused Meeting Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The present review surveys recent data on the structure and regulation of sGC, and the prospects of new avenues for therapeutic intervention. Portland Press Ltd. 2014-01-23 2014-02-01 /pmc/articles/PMC3901396/ /pubmed/24450636 http://dx.doi.org/10.1042/BST20130228 Text en © 2014 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biochemical Society Focused Meeting
Gileadi, Opher
Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
title Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
title_full Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
title_fullStr Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
title_full_unstemmed Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
title_short Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
title_sort structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
topic Biochemical Society Focused Meeting
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901396/
https://www.ncbi.nlm.nih.gov/pubmed/24450636
http://dx.doi.org/10.1042/BST20130228
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