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Diverse Metastable Structures Formed by Small Oligomers of α-Synuclein Probed by Force Spectroscopy
Oligomeric aggregates are widely suspected as toxic agents in diseases caused by protein aggregation, yet they remain poorly characterized, partly because they are challenging to isolate from a heterogeneous mixture of species. We developed an assay for characterizing structure, stability, and kinet...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901707/ https://www.ncbi.nlm.nih.gov/pubmed/24475132 http://dx.doi.org/10.1371/journal.pone.0086495 |