JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis

Pancreatic β-cell dysfunction is central to type 2 diabetes pathogenesis. Prolonged elevated levels of circulating free-fatty acids and hyperglycemia, also termed glucolipotoxicity, mediate β-cell dysfunction and apoptosis associated with increased c-Jun N-terminal Kinase (JNK) activity. Endoplasmic...

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Detalles Bibliográficos
Autores principales: Prause, Michala, Christensen, Dan Ploug, Billestrup, Nils, Mandrup-Poulsen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901710/
https://www.ncbi.nlm.nih.gov/pubmed/24475223
http://dx.doi.org/10.1371/journal.pone.0087067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901710/
https://www.ncbi.nlm.nih.gov/pubmed/24475223
http://dx.doi.org/10.1371/journal.pone.0087067

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