Cargando…

JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis

Pancreatic β-cell dysfunction is central to type 2 diabetes pathogenesis. Prolonged elevated levels of circulating free-fatty acids and hyperglycemia, also termed glucolipotoxicity, mediate β-cell dysfunction and apoptosis associated with increased c-Jun N-terminal Kinase (JNK) activity. Endoplasmic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prause, Michala, Christensen, Dan Ploug, Billestrup, Nils, Mandrup-Poulsen, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901710/ https://www.ncbi.nlm.nih.gov/pubmed/24475223 http://dx.doi.org/10.1371/journal.pone.0087067

Ejemplares similares

JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression
por: Prause, Michala, et al.
Publicado: (2016)

Butyrate Protects Pancreatic Beta Cells from Cytokine-Induced Dysfunction
por: Prause, Michala, et al.
Publicado: (2021)

Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells
por: Pedersen, Signe Schultz, et al.
Publicado: (2022)

Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in β-Cells
por: Dahlby, Tina, et al.
Publicado: (2020)

Targeted Delivery of Butyrate Improves Glucose Homeostasis, Reduces Hepatic Lipid Accumulation and Inflammation in db/db Mice
por: Pedersen, Signe Schultz, et al.
Publicado: (2023)

Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding
por: Urizar, Adriana Ibarra, et al.
Publicado: (2023)

The Adaptor Protein NumbL Is Involved in the Control of Glucolipotoxicity-Induced Pancreatic Beta Cell Apoptosis
por: Basavarajappa, Halesha D., et al.
Publicado: (2023)

Developmental Programming and Glucolipotoxicity: Insights on Beta Cell Inflammation and Diabetes
por: Cerf, Marlon E.
Publicado: (2020)

Yunvjian-Medicated Serum Protects INS-1 Cells against Glucolipotoxicity-Induced Apoptosis through Autophagic Flux Modulation
por: He, Caigu, et al.
Publicado: (2020)

Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells
por: Chen, Shiau-Mei, et al.
Publicado: (2021)

The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets
por: Ghiasi, Seyed Mojtaba, et al.
Publicado: (2020)

Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity
por: QiNan, Wu, et al.
Publicado: (2016)

Glucolipotoxicity in Pancreatic β-Cells
por: Kim, Ji-Won, et al.
Publicado: (2011)

Cardiac Glucolipotoxicity and Cardiovascular Outcomes
por: Cerf, Marlon E.
Publicado: (2018)

Glucolipotoxicity and GLP-1 secretion
por: Hong, Jung-Hee, et al.
Publicado: (2021)

Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c
por: Chen, Ke, et al.
Publicado: (2011)

Liraglutide protects against glucolipotoxicity‐induced RIN‐m5F β‐cell apoptosis through restoration of PDX1 expression
por: Kornelius, Edy, et al.
Publicado: (2018)

Nrf2 Activation Protects Mouse Beta Cells from Glucolipotoxicity by Restoring Mitochondrial Function and Physiological Redox Balance
por: Schultheis, Johanna, et al.
Publicado: (2019)

Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity
por: Small, Jonnell C., et al.
Publicado: (2022)

PKR inhibitors suppress endoplasmic reticulum stress and subdue glucolipotoxicity-mediated impairment of insulin secretion in pancreatic beta cells
por: YALÇIN, Abdullah, et al.
Publicado: (2020)

Protection against Glucolipotoxicity by High Density Lipoprotein in Human PANC-1 Hybrid 1.1B4 Pancreatic Beta Cells: The Role of microRNA
por: Tarlton, Jamie M.R., et al.
Publicado: (2021)

Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity—Nutraceutical Options
por: McCarty, Mark F., et al.
Publicado: (2021)

P38 Plays an Important Role in Glucolipotoxicity-Induced Apoptosis in INS-1 Cells
por: Zhou, Lingli, et al.
Publicado: (2014)

Glucolipotoxic Stress-Induced Mig6 Desensitizes EGFR Signaling and Promotes Pancreatic Beta Cell Death
por: Chen, Yi-Chun, et al.
Publicado: (2023)

FGF-23 protects cell function and viability in murine pancreatic islets challenged by glucolipotoxicity
por: Pajaziti, Betina, et al.
Publicado: (2022)

Combination of ferric ammonium citrate with cytokines involved in apoptosis and insulin secretion of human pancreatic beta cells related to diabetes in thalassemia
por: Rattanaporn, Patchara, et al.
Publicado: (2020)

The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition
por: Kwon, Min Jeong, et al.
Publicado: (2011)

Denosumab Attenuates Glucolipotoxicity-Induced β-Cell Dysfunction and Apoptosis by Attenuating RANK/RANKL Signals
por: Lin, Sheng-Chieh, et al.
Publicado: (2023)

The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β
por: Khilji, Muhammad Saad, et al.
Publicado: (2020)

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells
por: Grunnet, Lars G., et al.
Publicado: (2009)

Mesenchymal Stem Cells Ameliorated Glucolipotoxicity in HUVECs through TSG-6
por: An, Xingxing, et al.
Publicado: (2016)

Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis
por: Yang, Yiqi, et al.
Publicado: (2022)

Human Pancreatic Islets React to Glucolipotoxicity by Secreting Pyruvate and Citrate
por: Perrier, Johan, et al.
Publicado: (2023)

Mitigation of Glucolipotoxicity-Induced Apoptosis, Mitochondrial Dysfunction, and Metabolic Stress by N-Acetyl Cysteine in Pancreatic β-Cells
por: Alnahdi, Arwa, et al.
Publicado: (2020)

Berberine Protects Human Umbilical Vein Endothelial Cells against LPS-Induced Apoptosis by Blocking JNK-Mediated Signaling
por: Guo, Junping, et al.
Publicado: (2016)

Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis
por: Li, Jingjing, et al.
Publicado: (2015)

Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells
por: Liu, B, et al.
Publicado: (2001)

Divalent Metal Transporter 1 Knock-Down Modulates IL-1β Mediated Pancreatic Beta-Cell Pro-Apoptotic Signaling Pathways through the Autophagic Machinery
por: Kang, Taewook, et al.
Publicado: (2021)

ID’ing a Novel Inhibitor of β-Cell Function, Id1
por: Billestrup, Nils
Publicado: (2011)

The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity
por: Moreto, Fernando, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_51g273sbdtaiqrgpdbe17ec9im