Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK

BACKGROUND: The liver-specific glucokinase knockout (gck(w/–)) mouse experiences long-term hyperglycemia and insulin resistance. This study was designed to evaluate the functional and structural changes in the myocardium of 60 week-old gck(w/–) mice, and to investigate the effect of rosiglitazone on...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Hui, Wang, Xi, Mao, Yiqing, Hu, Ruobi, Xu, Wei, Lei, Zhen, Zhou, Na, Jin, Ling, Guo, Tingting, Li, Zhixin, Irwin, David M, Niu, Gang, Tan, Huanran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901845/
https://www.ncbi.nlm.nih.gov/pubmed/24447392
http://dx.doi.org/10.1186/1475-2840-13-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901845/
https://www.ncbi.nlm.nih.gov/pubmed/24447392
http://dx.doi.org/10.1186/1475-2840-13-24

Ejemplares similares