CD4(+)CD25(+) T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ / GARP-mediated mechanism

BACKGROUND: We and others have previously reported that cell membrane-bound TGFβ (mTGFβ) on activated T regulatory (Treg) cells mediates suppressor function. Current findings suggest that a novel protein known as Glycoprotein A Repetitions Predominant (GARP) anchors mTGFβ to the Treg cell surface an...

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Detalles Bibliográficos
Autores principales: Miller, Michelle M, Petty, Christopher S, Tompkins, Mary B, Fogle, Jonathan E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902059/
https://www.ncbi.nlm.nih.gov/pubmed/24438223
http://dx.doi.org/10.1186/1743-422X-11-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902059/
https://www.ncbi.nlm.nih.gov/pubmed/24438223
http://dx.doi.org/10.1186/1743-422X-11-7

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